KETOROLAC TRIS SALT
Ketorolac Tromethamine
CAS: 74103-07-4
Molecular Formula: C19H24N2O6
KETOROLAC TRIS SALT - Names and Identifiers
| Name | Ketorolac Tromethamine |
| Synonyms | Toradol Ketorolac tris salt KETOROLAC TRIS SALT KETOROLAC TROMETHAMINE Ketorolac Tromethamine (±)-Form tromethamine salt KETROLAC TROMETHAMINE SALT KETOROLAC TROMETHAMINE SALT |
| CAS | 74103-07-4 |
| InChI | InChI=1/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;6-2-1-5(3-7)4-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-4H2 |
| InChIKey | BWHLPLXXIDYSNW-UHFFFAOYSA-N |
KETOROLAC TRIS SALT - Physico-chemical Properties
| Molecular Formula | C19H24N2O6 |
| Molar Mass | 376.4 |
| Melting Point | 160-161 C |
| Solubility | H2O: 15mg/mL stable at least one month at −20 °C., soluble |
| Appearance | crystalline |
| Color | White to Light yellow |
| Maximum wavelength(λmax) | ['322nm(MeOH)(lit.)'] |
| Merck | 14,5306 |
| Storage Condition | 2-8°C |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC 50 s of 20 nM for COX-1 and 120 nM for COX-2. |
| In vivo study | Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits. Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group. |
KETOROLAC TRIS SALT - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UY7759900 |
| HS Code | 2933995500 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
KETOROLAC TRIS SALT - Reference Information
| Overview | ketorolac tromethamine is an alcoholic organic matter, its biological activity is related to L-S(-), which can inhibit prostaglandin biosynthesis. |
| Use | tromethamine pyrrolidine carboxylic acid derivatives are composed of L-(-) and D-(-) isomer of the racemate, the dextrorotatory S() isomer has analgesic effect. |
| biological activity | Ketorolac tromethamine is a synthetic derivative of pyridoxine cyclic carboxylic acid with anti-inflammatory, analgesic and antipyretic activities. It is a non-selective COX inhibitor with IC50 values of 20 nM for both COX-1 and COX-2. |
| Target | Value |
| COX1 () | 20 nM |
| COX2 () | 20 nM |
Last Update：2024-04-09 20:45:29
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